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Colorful Calcium Sensors
Author(s) -
Lindenburg Laurens,
Merkx Maarten
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100739
Subject(s) - palette (painting) , calcium , toolbox , calcium in biology , calcium signaling , computational biology , biology , chemistry , computer science , organic chemistry , programming language , operating system
(R)evolution of protein‐based calcium sensors: Expanding the toolbox of genetically encoded calcium sensors with new colors and traits is important for understanding calcium signaling and its relation to other intracellular pathways. Campbell and co‐workers have used a new directed‐evolution strategy to develop a rich palette of new sensors, including the first red‐shifted, genetically encoded calcium sensor.