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Redundant Pathways of Sunscreen Biosynthesis in a Cyanobacterium
Author(s) -
Spence Edward,
Dunlap Walter C.,
Shick J. Malcolm,
Long Paul F.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100737
Subject(s) - shikimic acid , biosynthesis , anabaena variabilis , pentose phosphate pathway , shikimate pathway , biochemistry , cyanobacteria , microcystin , metabolic pathway , biology , amino acid , anabaena , gene , chemistry , enzyme , bacteria , genetics , glycolysis
Route of the sun block: According to empirical evidence, sun‐screening mycosporine‐like amino acids (MAAs) in Eukarya originate from the shikimic acid pathway, whereas in cyanobacteria, biosynthesis of the MAA shinorine reportedly occurs through the pentose phosphate pathway. However, gene deletion shows that the cyanobacterium Anabaena variabilis ATCC 29143 does not biosynthesise shinorine exclusively by this route.