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Discrimination between T/A and A/T Base Pairs of Pyrrole‐Imidazole Polyamides Substituted with Chiral β‐Hydroxy‐γ‐Aminobutyric Acid/β‐Alanine Pairs
Author(s) -
Zhang Wen,
Jiang ShiKun,
Wu YanLing,
Guo ChuanXin,
Zhang HongFei,
Sugiyama Hiroshi,
Chen XingLai
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100675
Subject(s) - base pair , alanine , polyamide , minor groove , chemistry , dna , imidazole , base (topology) , flexibility (engineering) , combinatorial chemistry , stereochemistry , element (criminal law) , sequence (biology) , amino acid , computer science , biochemistry , organic chemistry , mathematics , law , mathematical analysis , statistics , political science
Base‐T‐specific recognition element: A chiral aliphatic amino acid, ( S )‐β‐hydroxyl‐γ‐aminobutyric acid, when incorporated into polyamides, can act as a novel T‐specific recognition element in DNA minor groove sequence‐specific recognition event. Good flexibility of the novel T‐reader implies that it could be incorporated into longer polyamides to regulate their curvature and thus allow discrimination of longer DNA sequences.