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Solubilized Gramicidin A as Potential Systemic Antibiotics
Author(s) -
Wang Fang,
Qin Luoheng,
Pace Christopher J.,
Wong Patrick,
Malonis Ryan,
Gao Jianmin
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100671
Subject(s) - gramicidin s , antibiotics , antimicrobial peptides , mutant , gramicidin , solubilization , computational biology , antimicrobial , chemistry , peptide , microbiology and biotechnology , biochemistry , biology , membrane , gene
Makeover of an old antibiotic: The channel‐forming toxin gramicidin A (gA) has been successfully converted into agents that selectively chase after bacterial cells. These novel D ‐Lys‐containing gA mutants display potent antimicrobial activity and remarkable therapeutic indexes (>1000‐fold).