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The Natural Product Betulinic Acid Inhibits C/EBP Family Transcription Factors
Author(s) -
Hollis Angela,
Sperl Bianca,
Gräber Martin,
Berg Thorsten
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100652
Subject(s) - betulinic acid , transcription factor , natural product , transcription (linguistics) , chemistry , adipogenesis , carcinogenesis , biochemistry , biology , genetics , gene , linguistics , philosophy
Nature does it : Small‐molecule inhibitors of transcription factors are highly sought after, but only a limited number are known to date. Here, we report the pentacyclic triterpenoid betulinic acid as a pan‐specific inhibitor of the C/EBP transcription factor family, proteins that play prominent roles in adipogenesis and tumorigenesis.