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Imaging the Sialome during Zebrafish Development with Copper‐Free Click Chemistry
Author(s) -
Dehnert Karen W.,
Baskin Jeremy M.,
Laughlin Scott T.,
Beahm Brendan J.,
Naidu Natasha N.,
Amacher Sharon L.,
Bertozzi Carolyn R.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100649
Subject(s) - click chemistry , chemistry , zebrafish , azide , copper , glycan , glycolipid , glycoprotein , sialic acid , live cell imaging , cell , biochemistry , microbiology and biotechnology , biophysics , combinatorial chemistry , biology , organic chemistry , gene
The sialome comprises sialylated glycoproteins and glycolipids that play essential roles in cell–cell communication. Using azide‐modified molecular precursors of sialic acids and copper‐free click chemistry, we visualized the spatiotemporal dynamics of the sialome in live zebrafish embryos.