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Sequence‐Unrestricted, Watson–Crick Recognition of Double Helical B‐DNA by ( R )‐MiniPEG‐γPNAs
Author(s) -
Bahal Raman,
Sahu Bichismita,
Rapireddy Srinivas,
Lee ChongMin,
Ly Danith H.
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100646
Subject(s) - molecular structure of nucleic acids: a structure for deoxyribose nucleic acid , nucleic acid , dna , base pair , sequence (biology) , peptide nucleic acid , watson , stereochemistry , nucleic acid analogue , chemistry , triple helix , computational biology , biology , biochemistry , base sequence , nucleic acid thermodynamics , computer science , natural language processing
Invasion of the strand snatchers : We have synthesized chiral γ‐peptide nucleic acids containing miniPEG side chains. Using gel shift assays we show that this particular type of nucleic acid mimic can invade any sequence of double helical B‐form DNA (see figure), and this recognition occurs through direct Watson–Crick base pairing.