Expansion of the Amino Acid Repertoire in Protein Biosynthesis in Silkworm Cells | Zendy

Teramoto Hidetoshi | Zendy; Kojima Katsura | Zendy; Kajiwara Hideyuki | Zendy; Ishibashi Jun | Zendy

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Expansion of the Amino Acid Repertoire in Protein Biosynthesis in Silkworm Cells

Author(s) -

Teramoto Hidetoshi,

Kojima Katsura,

Kajiwara Hideyuki,

Ishibashi Jun

Publication year - 2012

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201100624

Subject(s) - aminoacyl trna synthetase , amino acid , biochemistry , biosynthesis , protein biosynthesis , protein engineering , mutant , bombyx mori , aminoacylation , green fluorescent protein , chemistry , transfer rna , substrate specificity , biology , enzyme , gene , rna

Toward silk production with UAAs : The strategy for residue‐specific incorporation of unnatural amino acids (UAAs) into proteins was extended to silkworm cells. Here we report the incorporation of p ‐Cl‐Phe into a reporter protein (EGFP) synthesized in silkworm cells that express an αA450G mutant of B. mori phenylalanyl‐tRNA synthetase with relaxed substrate specificity.

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