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Template‐Directed RNA Polymerization: The Taming of the Milieu
Author(s) -
Lehman Niles,
Hayden Eric J.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100611
Subject(s) - rna , rna world hypothesis , nucleotide , computational biology , abiogenesis , polymerization , chemistry , biology , biochemistry , genetics , ribozyme , gene , polymer , organic chemistry
No‐bias binding: The abiotic template‐directed synthesis of RNA could have been a key process in the origins of life on Earth. Recreating this process in the laboratory has been challenging, yet a combination of strategies has given rise to a synthesis that is both efficient and unbiased against any of the four nucleotides.