Premium
P450 BM3 on Steroids: The Swiss Army Knife P450 Enzyme Just Gets Better
Author(s) -
Wong LuetLok
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100606
Subject(s) - stereoselectivity , regioselectivity , chemistry , catalysis , enzyme , stereochemistry , mutant , medicinal chemistry , organic chemistry , biochemistry , gene
The catalytic regio‐ and stereoselective oxidation of aliphatic CH bonds by using atmospheric dioxygen as the oxidant is a highly desirable reaction. Reetz and co‐workers have recently reported the development of P450 BM3 mutants that oxidise testosterone with greatly increased turnover activity, total stereoselectivity and >95 % regioselectivity.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom