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Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides
Author(s) -
Zheng JiShen,
Tang Shan,
Guo Ye,
Chang HaoNan,
Liu Lei
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100580
Subject(s) - cyclic peptide , peptide , chemistry , epimer , chemical ligation , intramolecular force , combinatorial chemistry , ligation , peptide synthesis , native chemical ligation , stereochemistry , biochemistry , chemical synthesis , biology , microbiology and biotechnology , in vitro
Intramolecular ligation of peptide hydrazides is reported to occur readily, causing the lactamization of fully unprotected peptides in an epimerization‐free manner. This method relies on the routine procedures of Fmoc solid‐phase peptide synthesis. It can be used to prepare cyclic peptides and cyclic proteins under simpler, mild conditions at lower costs.