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Photoswitchable Click Amino Acids: Light Control of Conformation and Bioactivity
Author(s) -
Hoppmann Christian,
Schmieder Peter,
Heinrich Nadja,
Beyermann Michael
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100578
Subject(s) - photoswitch , click chemistry , azobenzene , amino acid , intramolecular force , cysteine , chemistry , in vivo , photoisomerization , combinatorial chemistry , stereochemistry , photochemistry , biochemistry , molecule , organic chemistry , biology , catalysis , isomerization , microbiology and biotechnology , enzyme
Click the switch: By using a photoswitchable click amino acid (PSCaa) a light‐induced intramolecular thiol‐ene click reaction with a neighboring cysteine under very mild conditions results in an azobenzene bridge (see figure). By expanding the genetic code for PSCaa the specific incorporation of photoswitch units into proteins in living cells can result in an exciting approach for studying light‐controllable activity, in vivo.