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In Situ RBL Receptor Visualization and Its Mediated Anticancer Activity for Solasodine Rhamnosides
Author(s) -
Wang Yanyan,
Gao Jian,
Gu Guofeng,
Li Gang,
Cui Changzhi,
Sun Bin,
Lou Hongxiang
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100551
Subject(s) - solasodine , in situ , cell culture , cancer cell lines , receptor , computational biology , chemistry , computer science , cancer cell , cancer research , solanum , biology , biochemistry , cancer , genetics , botany , organic chemistry
Made visible: In situ visualization of the RBL receptor on cancer cell line surfaces was developed by using biotinylated rhamnose and chacotriose bound to quantum dots. The RBL receptor showed different expression patterns on various cell lines. Also, solasodine rhamnosides were found to kill cancer cells more effectively (see graphic). The finding of the RBL receptor‐mediated anticancer activity could help the design of chemotherapy agents.