Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication that Amyloid Cytotoxicity Is Correlated with Prolonged Cellular Binding | Zendy

Zako Tamotsu | Zendy; Sakono Masafumi | Zendy; Kobayashi Takahiro | Zendy; Sörgjerd Karin | Zendy; Nilsson K. Peter R. | Zendy; Hammarström Per | Zendy; Lindgren Mikael | Zendy; Maeda Mizuo | Zendy

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Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication that Amyloid Cytotoxicity Is Correlated with Prolonged Cellular Binding

Author(s) -

Zako Tamotsu,

Sakono Masafumi,

Kobayashi Takahiro,

Sörgjerd Karin,

Nilsson K. Peter R.,

Hammarström Per,

Lindgren Mikael,

Maeda Mizuo

Publication year - 2012

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201100467

Subject(s) - amyloid (mycology) , cytotoxicity , chemistry , biochemistry , conjugated system , polythiophene , toxicity , computational biology , biology , in vitro , polymer , organic chemistry , inorganic chemistry , conductive polymer

Needles and noodles : Studying amyloid toxicity is important for understanding protein misfolding diseases. Using a luminescent conjugated polythiophene, we found that cell binding of nontoxic filamentous amyloids of insulin and β2‐microglobulin was less efficient than that of toxic fibrillar amyloids; this suggests a correlation between amyloid toxicity and cell binding.

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