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Cell Interaction Study of Amyloid by Using Luminescent Conjugated Polythiophene: Implication that Amyloid Cytotoxicity Is Correlated with Prolonged Cellular Binding
Author(s) -
Zako Tamotsu,
Sakono Masafumi,
Kobayashi Takahiro,
Sörgjerd Karin,
Nilsson K. Peter R.,
Hammarström Per,
Lindgren Mikael,
Maeda Mizuo
Publication year - 2012
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100467
Subject(s) - amyloid (mycology) , cytotoxicity , chemistry , biochemistry , conjugated system , polythiophene , toxicity , computational biology , biology , in vitro , polymer , organic chemistry , inorganic chemistry , conductive polymer
Needles and noodles : Studying amyloid toxicity is important for understanding protein misfolding diseases. Using a luminescent conjugated polythiophene, we found that cell binding of nontoxic filamentous amyloids of insulin and β2‐microglobulin was less efficient than that of toxic fibrillar amyloids; this suggests a correlation between amyloid toxicity and cell binding.