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Genome Mining Reveals Two Novel Bacterial Sesquiterpene Cyclases: (−)‐Germacradien‐4‐ol and (−)‐ epi ‐α‐Bisabolol Synthases from Streptomyces citricolor
Author(s) -
Nakano Chiaki,
Kudo Fumitaka,
Eguchi Tadashi,
Ohnishi Yasuo
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100418
Subject(s) - genome , sesquiterpene , streptomyces , biology , bacteria , whole genome sequencing , terpenoid , gene , cyclase , bacterial genome size , genetics , computational biology , biochemistry , botany , enzyme
Now found in bacteria: An increasing number of genome sequences indicate that bacteria possess a variety of terpenoid cyclase genes. The characterization of two sesquiterpene cyclase (SC) genes found in the draft genome sequence of Streptomyces citricolor is described here. Our study strongly supports the idea that genome mining is a useful approach in revealing the terpenoid diversity in bacteria.