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Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement
Author(s) -
Macmillan Derek,
De Cecco Martin,
Reynolds Natalie L.,
Santos Luiz F. A.,
Barran Perdita E.,
Dorin Julia R.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100364
Subject(s) - intramolecular force , cyclic peptide , native chemical ligation , chemistry , combinatorial chemistry , amide , peptide bond , stereochemistry , peptide , chemical synthesis , biochemistry , in vitro
Latent thioesters: Reverse native chemical ligation followed by intramolecular trans‐thioesterification and acyl transfer can rearrange linear peptides into biologically active cyclic products.