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A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome
Author(s) -
Kumar Amit,
Fang Pengfei,
Park Hajeung,
Guo Min,
Nettles Kendall W.,
Disney Matthew D.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100337
Subject(s) - fragile x syndrome , rna , fragile x , crystal structure , genetics , nucleic acid structure , biology , rna binding protein , computational biology , crystallography , chemistry , gene
A birds eye view of fragile X syndrome: A crystal structure of the r(CGG) repeat in fragile X syndrome is reported. The structure enables a high‐resolution view of a unique RNA structure. It can also be used to design drugs targeting the RNA that causes this untreatable disease.