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Using Modularly Assembled Ligands To Bind RNA Internal Loops Separated by Different Distances
Author(s) -
ChildsDisney Jessica L.,
Tsitovich Pavel B.,
Disney Matthew D.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100298
Subject(s) - rna , biomolecule , ligand (biochemistry) , computational biology , benzimidazole , modular design , chemistry , biology , biophysics , combinatorial chemistry , biochemistry , nanotechnology , computer science , receptor , materials science , programming language , organic chemistry , gene
Looped in: Modular assembly provides a unique opportunity to tune the affinity and specificity of ligands for a target biomolecule. Herein, we describe our investigations into how the distance between bis‐benzimidazole ligand modules (see graphic) affects affinity and specificity for RNA internal loops.