Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats | Zendy

Hagihara Masaki | Zendy; He Hanping | Zendy; Nakatani Kazuhiko | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats

Author(s) -

Hagihara Masaki,

He Hanping,

Nakatani Kazuhiko

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201100260

Subject(s) - trinucleotide repeat expansion , dna , genetics , biology , dna replication , dna polymerase , polymerase , genome , repeated sequence , computational biology , dna clamp , sequence (biology) , microbiology and biotechnology , polymerase chain reaction , gene , allele , reverse transcriptase

Spanner in the works: The synthetic ligand, naphthyridine‐azaquinolone (NA), can induce hairpin secondary structures on d(CAG) n repeats and efficiently interfere with DNA replication by Taq DNA polymerase as well as the human DNA polymerase α (see figure). Considering its unique sequence preference, NA would be a valuable probe to understand the features of the genetic instabilities of CAG/CTG repeat sequences in genomes.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research