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Small Molecule Modulates Hairpin Structures in CAG Trinucleotide Repeats
Author(s) -
Hagihara Masaki,
He Hanping,
Nakatani Kazuhiko
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100260
Subject(s) - trinucleotide repeat expansion , dna , genetics , biology , dna replication , dna polymerase , polymerase , genome , repeated sequence , computational biology , dna clamp , sequence (biology) , microbiology and biotechnology , polymerase chain reaction , gene , allele , reverse transcriptase
Spanner in the works: The synthetic ligand, naphthyridine‐azaquinolone (NA), can induce hairpin secondary structures on d(CAG) n repeats and efficiently interfere with DNA replication by Taq DNA polymerase as well as the human DNA polymerase α (see figure). Considering its unique sequence preference, NA would be a valuable probe to understand the features of the genetic instabilities of CAG/CTG repeat sequences in genomes.