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Efficient Suppression of Gene Expression by Targeting 5′‐UTR‐Based RNA Quadruplexes with Bisquinolinium Compounds
Author(s) -
Halder Kangkan,
Largy Eric,
Benzler Martin,
TeuladeFichou MariePaule,
Hartig Jörg S.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100228
Subject(s) - untranslated region , rna , gene , three prime untranslated region , computational biology , gene expression , biology , genetics , g quadruplex , five prime untranslated region , dna
Fourth amendment: RNA quadruplexes located in the 5′‐untranslated regions (5′‐UTR in the figure) of mRNAs inhibit gene expression. This effect can be amplified by targeting RNA quadruplexes with specific bisquinolinium compounds.