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Cytotoxic Fatty Acid Amides from Xenorhabdus
Author(s) -
Proschak Anna,
Schultz Katharina,
Herrmann Jennifer,
Dowling Andrea J.,
Brachmann Alexander O.,
ffrenchConstant Richard,
Müller Rolf,
Bode Helge B.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100223
Subject(s) - chemistry , amide , chemical structure , tryptamine , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry
Simple and bioactive: 26 acyl amides have been identified in cultures of different Xenorhabdus strains and several analogues have been synthesised. Despite their simple chemical structure, several of these compounds show cytotoxicity against mammalian cell lines and insect haemocytes, thus indicating that they have a role in the complex life cycle of these bacteria.