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Photocontrol of Peptide Function: Backbone Cyclization Strategy with Photocleavable Amino Acid
Author(s) -
Umezawa Naoki,
Noro Yuka,
Ukai Kazuhiro,
Kato Nobuki,
Higuchi Tsunehiko
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100212
Subject(s) - peptide , cyclic peptide , function (biology) , amino acid , combinatorial chemistry , chemistry , biochemistry , biology , microbiology and biotechnology
Light‐switchable peptide: The combination of cyclization and a photocleavable amino acid provides a potentially versatile strategy for the photocontrol of peptide function. Upon photoirradiation, photoactivatable cyclic matrix metalloproteinase‐3 inhibitor peptide (MMPI) was degraded to give the corresponding linear product (see scheme), which showed 47‐fold stronger activity than the parent cyclic MMPI.