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Mechanistically Distinct Nonribosomal Peptide Synthetases Assemble the Structurally Related Antibiotics Viomycin and Capreomycin
Author(s) -
Felnagle Elizabeth A.,
Podevels Angela M.,
Barkei John J.,
Thomas Michael G.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100193
Subject(s) - viomycin , nonribosomal peptide , capreomycin , peptide , biology , biochemistry , chemistry , biosynthesis , antibiotics , enzyme , ethambutol , streptomycin
Tuberactinomycin biosynthesis: Viomycin and capreomycin are structurally related antituberculosis drugs. Analysis of the nonribosomal peptide synthetases that assemble these molecules determined that peptide assembly occurs by distinct mechanisms. These unexpected differences provide insights into how modifications to homologous nonribosomal peptide synthetases can result in structure diversification.