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Osteocalcin Biomimic Recognizes Bone Hydroxyapatite
Author(s) -
Lee Jae Sam,
Tung ChingHsuan
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100162
Subject(s) - osteocalcin , peptide , bone formation , chemistry , computer science , computational biology , biochemistry , nanotechnology , biology , medicine , materials science , enzyme , alkaline phosphatase
Twinkle, twinkle little bone! A short peptide derived from a natural bone binding protein, osteocalcin, shows excellent selectivity and affinity to hydroxyapatite, the main component of bone. With a fluorescent label, the intravenously injected peptide revealed detailed bone structures in mice, like an X‐ray image (see figure).