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Hyperconjugation Contributes to the Bimodal Distribution of Glycine Conformations Observed in Protein Three‐Dimensional Structures
Author(s) -
Wathen Brent,
Pratt Derek A.,
Jia Zongchao
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100156
Subject(s) - glycine , steric effects , hyperconjugation , chemistry , stereochemistry , crystallography , computational chemistry , molecule , amino acid , biochemistry , organic chemistry
Despite their flexible natures , glycine residues adopt only a subset of their sterically available conformations in protein structures. With the aid of quantum calculations we have found that hyperconjugation plays a significant role in influencing glycine conformations by stabilizing planar backbone orientations.