Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones | Zendy

Scherlach Kirstin | Zendy; Sarkar Anindita | Zendy; Schroeckh Volker | Zendy; Dahse HansMartin | Zendy; Roth Martin | Zendy; Brakhage Axel A. | Zendy; Horn Uwe | Zendy; Hertweck Christian | Zendy

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Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones

Author(s) -

Scherlach Kirstin,

Sarkar Anindita,

Schroeckh Volker,

Dahse HansMartin,

Roth Martin,

Brakhage Axel A.,

Horn Uwe,

Hertweck Christian

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201100132

Subject(s) - polyketide , chemostat , aspergillus nidulans , polyketide synthase , biology , aspergillus , biosynthesis , limiting , gene , fungus , biochemistry , microbiology and biotechnology , computational biology , genetics , bacteria , mutant , botany , mechanical engineering , engineering

Unite in times of deprivation: We report on the use of a chemostat to elicit cryptic biosynthetic pathways in a fungus. Cutlivation of Aspergillus nidulans under N‐limiting conditions in a chemostat led to the specific induction of polyketide biosynthesis genes that were otherwise silent. The merger of an anthraquinone with an orsellinic acid‐derived oxanthrene yielded two spiroanthrones, sanghaspirodins A and B (see figure).

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