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Two Induced Fungal Polyketide Pathways Converge into Antiproliferative Spiroanthrones
Author(s) -
Scherlach Kirstin,
Sarkar Anindita,
Schroeckh Volker,
Dahse HansMartin,
Roth Martin,
Brakhage Axel A.,
Horn Uwe,
Hertweck Christian
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100132
Subject(s) - polyketide , chemostat , aspergillus nidulans , polyketide synthase , biology , aspergillus , biosynthesis , limiting , gene , fungus , biochemistry , microbiology and biotechnology , computational biology , genetics , bacteria , mutant , botany , mechanical engineering , engineering
Unite in times of deprivation: We report on the use of a chemostat to elicit cryptic biosynthetic pathways in a fungus. Cutlivation of Aspergillus nidulans under N‐limiting conditions in a chemostat led to the specific induction of polyketide biosynthesis genes that were otherwise silent. The merger of an anthraquinone with an orsellinic acid‐derived oxanthrene yielded two spiroanthrones, sanghaspirodins A and B (see figure).