Site‐Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations | Zendy

Bernardes Gonçalo J. L. | Zendy; Linderoth Lars | Zendy; Doores Katie J. | Zendy; Boutureira Omar | Zendy; Davis Benjamin G. | Zendy

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Site‐Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations

Author(s) -

Bernardes Gonçalo J. L.,

Linderoth Lars,

Doores Katie J.,

Boutureira Omar,

Davis Benjamin G.

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201100125

Subject(s) - scope (computer science) , computer science , azide , chemistry , computational biology , glycoprotein , combinatorial chemistry , information retrieval , biochemistry , programming language , biology , organic chemistry

Making it traceless: A traceless Staudinger reaction between a specifically functionalized sugar phosphine and an azide‐tagged protein allows the construction of well‐defined reverse N ‐linked glycoproteins (see scheme). This reaction was applied to different azidoprotein substrates and its potentials and limitations are outlined.

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