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Site‐Selective Traceless Staudinger Ligation for Glycoprotein Synthesis Reveals Scope and Limitations
Author(s) -
Bernardes Gonçalo J. L.,
Linderoth Lars,
Doores Katie J.,
Boutureira Omar,
Davis Benjamin G.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100125
Subject(s) - scope (computer science) , computer science , azide , chemistry , computational biology , glycoprotein , combinatorial chemistry , information retrieval , biochemistry , programming language , biology , organic chemistry
Making it traceless: A traceless Staudinger reaction between a specifically functionalized sugar phosphine and an azide‐tagged protein allows the construction of well‐defined reverse N ‐linked glycoproteins (see scheme). This reaction was applied to different azidoprotein substrates and its potentials and limitations are outlined.