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Identification and Characterization of New Inhibitors of Fungal Homoserine Kinase
Author(s) -
De Pascale Gianfranco,
Griffiths Emma J.,
Shakya Tushar,
Nazi Ishac,
Wright Gerard D.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100121
Subject(s) - homoserine , antimicrobial , biochemistry , kinase , chemistry , biology , microbiology and biotechnology , computational biology , quorum sensing , gene , virulence
The aspartate pathway in fungi is a well‐validated antimicrobial target. Deletion of homoserine kinase ( THR1 ) has been proven to lead to a chemical‐synthetic lethal phenotype in the presence of several bioactive molecules. We have identified and characterized several Thr1 inhibitors that can be used in combination therapy against fungal infections.