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Feglymycin is an Inhibitor of the Enzymes MurA and MurC of the Peptidoglycan Biosynthesis Pathway
Author(s) -
Rausch Saskia,
Hänchen Anne,
Denisiuk Alexander,
Löhken Marius,
Schneider Tanja,
Süssmuth Roderich D.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100120
Subject(s) - enzyme , biosynthesis , mura , biochemistry , computational biology , streptomyces , peptidoglycan , biology , chemistry , bacteria , genetics , computer science , liquid crystal display , operating system
Selective inhibition: Feglymycin, a natural 13‐mer peptide antibiotic from Streptomyces sp. with activity against MRSA strains was tested in a one‐pot assay against the enzymes MurA–F from E. coli. Dereplication revealed that feglymycin specifically inhibits the enzymes MurA and MurC. Feglymycin is therefore the first natural inhibitor of MurC.