Premium
Identification of Novel Quadruplex Ligands from Small Molecule Libraries by FRET‐Based High‐Throughput Screening
Author(s) -
Benz Armin,
Singh Vijay,
Mayer Thomas U.,
Hartig Jörg S.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100094
Subject(s) - g quadruplex , computational biology , small molecule , identification (biology) , computer science , combinatorial chemistry , sequence (biology) , förster resonance energy transfer , information retrieval , chemistry , biology , biochemistry , dna , physics , fluorescence , botany , quantum mechanics
Quadruple alliance: By performing a screen for binders of the human telomeric repeat sequence with small molecule libraries, the principle of which is outlined in the scheme, we have identified novel compounds that stabilise the G quadruplex structure. Some of these could be suitable leads for further optimisation as potent and selective quadruplex ligands.