Synthesis of 5,6‐Spiroethers and Evaluation of their Affinities for the Bacterial A Site | Zendy

Katsoulis Ioannis A. | Zendy; Kythreoti Georgia | Zendy; Papakyriakou Athanasios | Zendy; Koltsida Konstantina | Zendy; Anastasopoulou Panoula | Zendy; Stathakis Christos I. | Zendy; Mavridis Ioannis | Zendy; Cottin Thomas | Zendy; Saridakis Emmanuel | Zendy; Vourloumis Dionisios | Zendy

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Synthesis of 5,6‐Spiroethers and Evaluation of their Affinities for the Bacterial A Site

Author(s) -

Katsoulis Ioannis A.,

Kythreoti Georgia,

Papakyriakou Athanasios,

Koltsida Konstantina,

Anastasopoulou Panoula,

Stathakis Christos I.,

Mavridis Ioannis,

Cottin Thomas,

Saridakis Emmanuel,

Vourloumis Dionisios

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201100076

Subject(s) - affinities , rna , binding affinities , ribosomal rna , chemistry , computational biology , combinatorial chemistry , binding site , stereochemistry , biology , biochemistry , gene , receptor

Exploring RNA recognition: Maximizing affinity for the A site of ribosomal RNA is a task met with a set of spirocyclic compounds that are presented in this work. The chemical syntheses, the biological evaluation and a computational justification of this interesting low‐n M fluorescence‐based activity are presented.

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