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Synthesis of 5,6‐Spiroethers and Evaluation of their Affinities for the Bacterial A Site
Author(s) -
Katsoulis Ioannis A.,
Kythreoti Georgia,
Papakyriakou Athanasios,
Koltsida Konstantina,
Anastasopoulou Panoula,
Stathakis Christos I.,
Mavridis Ioannis,
Cottin Thomas,
Saridakis Emmanuel,
Vourloumis Dionisios
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100076
Subject(s) - affinities , rna , binding affinities , ribosomal rna , chemistry , computational biology , combinatorial chemistry , binding site , stereochemistry , biology , biochemistry , gene , receptor
Exploring RNA recognition: Maximizing affinity for the A site of ribosomal RNA is a task met with a set of spirocyclic compounds that are presented in this work. The chemical syntheses, the biological evaluation and a computational justification of this interesting low‐n M fluorescence‐based activity are presented.