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Generation of Novel Nucleases with Extended Specificity by Rational and Combinatorial Strategies
Author(s) -
Pingoud Alfred,
Wende Wolfgang
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100055
Subject(s) - cleave , genome engineering , computational biology , genome editing , synthetic biology , protein engineering , computer science , genome , nanotechnology , dna , biology , genetics , enzyme , gene , biochemistry , materials science
The cutting crew: Programmable, highly specific endonucleases are indispensable tools for the emerging genome‐engineering technology. Different protein scaffolds (see picture) can be utilized to engineer these endonucleases, which ideally cleave once in a genome of interest.
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