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Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J
Author(s) -
Trigili Chiara,
Pera Benet,
Barbazanges Marion,
Cossy Janine,
Meyer Christophe,
Pineda Oriol,
RodríguezEscrich Carles,
Urpí Fèlix,
Vilarrasa Jaume,
Díaz J. Fernando,
Barasoain Isabel
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201100042
Subject(s) - chemistry , monomer , mechanism of action , stereochemistry , actin , in vitro , cytotoxic t cell , mechanism (biology) , biochemistry , organic chemistry , philosophy , epistemology , polymer
Acting on actin: The mechanism of action of amphidinolide X and amphidinolide J, two relatively small cytotoxic macrolides, has been elucidated. They do not target microtubules and intermediate filaments. The effects observed in A549 and PtK2 cells and the in vitro interaction with actin monomer (G‐actin) indicate that these macrolides behave as actin‐assembly inhibitors.