Premium
Inside Cover: A Potential Antitumor Drug (Arginine Deiminase) Reengineered for Efficient Operation under Physiological Conditions (ChemBioChem 16/2010)
Author(s) -
Zhu Leilei,
Verma Rajni,
Roccatano Danilo,
Ni Ye,
Sun ZhiHao,
Schwaneberg Ulrich
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201090078
Subject(s) - cover (algebra) , arginine deiminase , enzyme kinetics , protein data bank (rcsb pdb) , drug , chemistry , arginine , combinatorial chemistry , biochemistry , pharmacology , biology , amino acid , enzyme , active site , engineering , mechanical engineering
The inside cover picture shows the tetrameric model (based on PaADI, PDB ID: 2A9G) of the K5T/D38H/D44E/A128T/E296K/H404R variant of the potential antitumor protein drug PpADI. The highlighted substitutions significantly improve kcat (64.7 times higher) and/or reduce the S0.5 value (62 % that of wild‐type PpADI). For further information, see the paper by U. Schwaneberg, et al. on p. 2294 ff.