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Inside Cover: Membrane‐Surface Anchoring of Charged Diacylglycerol‐Lactones Correlates with Biological Activities (ChemBioChem 14/2010)
Author(s) -
Raifman Or,
Kolusheva Sofiya,
El Kazzouli Said,
Sigano Dina M.,
Kedei Noemi,
Lewin Nancy E.,
LopezNicolas Ruben,
OrtizEspin Ana,
GomezFernandez Juan C.,
Blumberg Peter M.,
Marquez Victor E.,
CorbalanGarcia Senena,
Jelinek Raz
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201090068
Subject(s) - diacylglycerol kinase , lactone , chemistry , lipid bilayer , biophysics , bilayer , membrane , confocal microscopy , stereochemistry , derivative (finance) , phospholipid , biochemistry , protein kinase c , biology , microbiology and biotechnology , signal transduction , financial economics , economics
The inside cover picture shows the molecular structure of a DAG lactone derivative on top of the inner leaflet of a DMPC bilayer. The confocal microscopy image illustrates DAG‐lactone‐stimulated membrane localization of PKCδ‐ECFP in living cells, while the space‐filling model shows the surface of the C1B domain of PKCδ, the target of the lactone. For more information, see the paper by V. E. Marquez, S. Corbalan‐Garcia, R. Jelinek et al. on p. 2003 ff.