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Cover Picture: Designed Short Peptides that Form Amyloid‐Like Fibrils in Coassembly with Amyloid β‐Peptide (Aβ) Decrease the Toxicity of Aβ to Neuronal PC12 Cells (ChemBioChem 11/2010)
Author(s) -
Suzuki Miho,
Takahashi Tsuyoshi,
Sato Junichi,
Mie Masayasu,
Kobatake Eiry,
Mihara Hisakazu
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201090048
Subject(s) - peptide , fibril , amyloid (mycology) , amyloid fibril , chemistry , p3 peptide , toxicity , biophysics , amyloid β , biochemistry , amyloid precursor protein , alzheimer's disease , biology , medicine , organic chemistry , inorganic chemistry , disease
The cover picture shows that a designed peptide can transform toxic amyloid oligomers into less‐toxic structures. The designed peptide, which has leucine and naphthylalanine at positions 6 and 7, respectively, coassembled with amyloid β‐peptide (Aβ) 1–42 oligomers into amyloid‐like fibrils. The toxicity of the amyloid‐like fibrils against neuronal PC12 cells was found to be much lower than that of Aβ oligomers. For more information, see the communication by H. Mihara et al. on p. 1525 ff.