Premium
Inside Cover: Unnatural Polyketide Analogues Selectively Target the HER Signaling Pathway in Human Breast Cancer Cells (ChemBioChem 4/2010)
Author(s) -
Kwon Seok Joon,
Kim Moon Il,
Ku Bosung,
Coulombel Lydie,
Kim JinHwan,
Shawky Joseph H.,
Linhardt Robert J.,
Dordick Jonathan S.
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201090011
Subject(s) - chalcone , polyketide , pi3k/akt/mtor pathway , polyketide synthase , signal transduction , chemistry , chalcone synthase , receptor , in vitro , cover (algebra) , biochemistry , computational biology , stereochemistry , microbiology and biotechnology , enzyme , biology , biosynthesis , mechanical engineering , engineering
The inside cover picture shows the inhibition of multiple HER receptors by unnatural polyketide analogues synthesized by using in vitro precursor‐directed chalcone synthase (CHS) catalysis. For further information on how the inhibition of multiple HER receptors has the potential to improve anticancer therapy by intensifying the inhibition of subsequent cellular signaling pathways (e.g., PI3K/Akt signal pathway) see the Full Paper by J. Dordick and co‐workers on p. 573 ff.