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Ruthenium(II) Metallo‐intercalators: DNA Imaging and Cytotoxicity
Author(s) -
Gill Martin R.,
Derrat Hanan,
Smythe Carl G. W.,
Battaglia Giuseppe,
Thomas Jim A.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000782
Subject(s) - ruthenium , cytotoxicity , dna , chemistry , intercalation (chemistry) , dna damage , biophysics , combinatorial chemistry , nanotechnology , biochemistry , biology , in vitro , materials science , organic chemistry , catalysis
Dead or alive: We report the successful cellular uptake of two ruthenium polypyridyl DNA light switch complexes that function as multifunctional cellular DNA imaging agents and display potent cytotoxicity against cancer cells. The cytotoxic properties of one complex are of great interest as it offers a potential lead for the development of a new class of anticancer drug in addition to its use as a cellular DNA imaging agent.