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Live Cell Luminescence Imaging As a Function of Delivery Mechanism
Author(s) -
Tian Xiaohe,
Gill Martin R.,
Cantón Irene,
Thomas Jim A.,
Battaglia Giuseppe
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000743
Subject(s) - polymersome , biocompatible material , biophysics , mechanism (biology) , ruthenium , luminescence , live cell imaging , chemistry , nanotechnology , function (biology) , cell , microbiology and biotechnology , materials science , biomedical engineering , biochemistry , biology , physics , medicine , catalysis , optoelectronics , organic chemistry , quantum mechanics , copolymer , amphiphile , polymer
Mitochondria in live cells can be imaged with a ruthenium(II) complex that usually binds and images nuclear DNA. The cellular uptake mechanism of this probe was changed by using a biocompatible pH‐sensitive polymersome vector. This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties.