Premium
Live Cell Luminescence Imaging As a Function of Delivery Mechanism
Author(s) -
Tian Xiaohe,
Gill Martin R.,
Cantón Irene,
Thomas Jim A.,
Battaglia Giuseppe
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000743
Subject(s) - polymersome , biocompatible material , biophysics , mechanism (biology) , ruthenium , luminescence , live cell imaging , chemistry , nanotechnology , function (biology) , cell , microbiology and biotechnology , materials science , biomedical engineering , biochemistry , biology , physics , medicine , catalysis , optoelectronics , organic chemistry , quantum mechanics , copolymer , amphiphile , polymer
Mitochondria in live cells can be imaged with a ruthenium(II) complex that usually binds and images nuclear DNA. The cellular uptake mechanism of this probe was changed by using a biocompatible pH‐sensitive polymersome vector. This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom