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Small‐Molecule Regulators of Human Stem Cell Self‐Renewal
Author(s) -
Bouchez Laure C.,
Boitano Anthony E.,
de Lichtervelde Lorenzo,
Romeo Russell,
Cooke Michael P.,
Schultz Peter G.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000734
Subject(s) - stem cell , aryl hydrocarbon receptor , haematopoiesis , computational biology , biology , cord blood , microbiology and biotechnology , gene , genetics , transcription factor
A cell‐based phenotypic screen using primary CD34 + cells identified novel regulators of hematopoietic stem cell (HSC) fate. These compounds expand cord‐blood‐derived HSCs by acting as potent antagonists of the aryl hydrocarbon receptor.