Universal Sensing by Transduction of Antibody Binding with Backscattering Interferometry | Zendy

Kussrow Amanda | Zendy; Baksh Michael M. | Zendy; Bornhop Darryl J. | Zendy; Finn M. G. | Zendy

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Universal Sensing by Transduction of Antibody Binding with Backscattering Interferometry

Author(s) -

Kussrow Amanda,

Baksh Michael M.,

Bornhop Darryl J.,

Finn M. G.

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201000671

Subject(s) - interferometry , computational biology , trace (psycholinguistics) , antibody , computer science , refractive index , range (aeronautics) , chemistry , biological system , biophysics , biology , materials science , optics , physics , genetics , philosophy , linguistics , composite material

All binding events induce a change in refractive index, and antibody–antigen interactions are no exception. We describe the use of backscattering interferometry to quantify antibody binding without labels and with high sensitivity. As a broad range of antibodies are available, this method represents a general way to selectively detect a wide variety of trace molecules in simple or complex mixtures.

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