Premium
Synthetic Caged DAG‐lactones for Photochemically Controlled Activation of Protein Kinase C
Author(s) -
Nomura Wataru,
Narumi Tetsuo,
Ohashi Nami,
Serizawa Yuki,
Lewin Nancy E.,
Blumberg Peter M.,
Furuta Toshiaki,
Tamamura Hirokazu
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000670
Subject(s) - protein kinase c , kinase , chemistry , affinities , chromosomal translocation , cascade , binding affinities , stereochemistry , biophysics , biochemistry , receptor , biology , chromatography , gene
Switching on kinases: Synthetic caged DAG‐lactones have been developed and showed decreases of two orders of magnitude, relative to the corresponding parent compounds, in their binding affinities towards PKC. The caged compounds had no effect on the translocation of PKC until after photoactivation. This approach is a potentially powerful tool for probing the PKC signaling cascade.