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Engineering Protein Switches: Sensors, Regulators, and Spare Parts for Biology and Biotechnology
Author(s) -
Golynskiy Misha V.,
Koay Melissa S.,
Vinkenborg Jan L.,
Merkx Maarten
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000642
Subject(s) - protein engineering , synthetic biology , spare part , mechanism (biology) , computational biology , biochemical engineering , nanotechnology , biology , engineering , biochemistry , physics , materials science , mechanical engineering , quantum mechanics , enzyme
Switch protein switch! Proteins that switch between distinct conformational states are ideal for monitoring and controlling molecular processes in biological systems. We discuss new engineering concepts for the construction of protein switches that have the potential to be generally applicable and discuss them according to their mechanism of action.