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Synthetic Peptidoglycan Motifs for Germination of Bacterial Spores
Author(s) -
Lee Mijoon,
Hesek Dusan,
Shah Ishita M.,
Oliver Allen G.,
Dworkin Jonathan,
Mobashery Shahriar
Publication year - 2010
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000626
Subject(s) - peptidoglycan , spore , germination , endospore , bacteria , spore germination , biology , microbiology and biotechnology , botany , genetics
Spore cheat: Certain important pathogenic bacteria can produce spores, which are a dormant cell type that is able to resist and survive unfavorable conditions. Environmental factors stimulate the germination of spores and result in regeneration of the bacterium. Minimal bacterial peptidoglycan motifs, prepared herein in multistep syntheses, potently stimulated spore germination in the low‐nanomolar range (see scheme).