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Rebeccamycin and Staurosporine Biosynthesis: Insight into the Mechanisms of the Flavin‐Dependent Monooxygenases RebC and StaC
Author(s) -
Groom Katherine,
Bhattacharya Anupam,
Zechel David L.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000580
Subject(s) - staurosporine , monooxygenase , chemistry , biosynthesis , flavin group , computational biology , stereochemistry , biochemistry , biology , gene , enzyme , protein kinase c , cytochrome p450
Once or twice? RebC and StaC are flavin‐dependent monooxygenases that occupy a key branch point in the biosynthesis of the indolocarbazoles rebeccamycin and staurosporine, respectively. A mere two substitutions in the active site of RebC was found to confer StaC reactivity.