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Cyclic RGD β‐Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells
Author(s) -
Aizpurua Jesus M.,
Ganboa José Ignacio,
Palomo Claudio,
Loinaz Iraida,
Oyarbide Joseba,
Fernandez Xabier,
Balentová Eva,
Fratila Raluca M.,
Jiménez Azucena,
Miranda José Ignacio,
Laso Antonio,
Ávila Silvia,
Castrillo José Luis
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000572
Subject(s) - peptidomimetic , tetrapeptide , chemistry , rgd motif , extracellular , gene , intracellular , microbiology and biotechnology , moiety , integrin , stereochemistry , biochemistry , biology , peptide , receptor
RGD peptidomimetics touch DNA: A few RGD cyclic peptidomimetics, each incorporating a densely substituted β‐lactam moiety, were prepared, and their effect on extracellular adhesion and intracellular gene regulation through α V β 3 integrin was studied in human endothelial cells (HUVECs). Surprisingly, the cyclic tetrapeptide with a deleted glycine residue and its parent RGD peptidomimetic displayed practically opposite angiogenic gene‐regulation activity.