The Discovery of Salinosporamide K from the Marine Bacterium “ Salinispora pacifica ” by Genome Mining Gives Insight into Pathway Evolution | Zendy

Eustáquio Alessandra S. | Zendy; Nam SangJip | Zendy; Penn Kevin | Zendy; Lechner Anna | Zendy; Wilson Micheal C. | Zendy; Fenical William | Zendy; Jensen Paul R. | Zendy; Moore Bradley S. | Zendy

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The Discovery of Salinosporamide K from the Marine Bacterium “ Salinispora pacifica ” by Genome Mining Gives Insight into Pathway Evolution

Author(s) -

Eustáquio Alessandra S.,

Nam SangJip,

Penn Kevin,

Lechner Anna,

Wilson Micheal C.,

Fenical William,

Jensen Paul R.,

Moore Bradley S.

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201000564

Subject(s) - genome , computational biology , biology , bacteria , gene , genetics

Evolving biosynthesis : Genome mining of the marine bacterium “ Salinispora pacifica ” has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.

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