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The Discovery of Salinosporamide K from the Marine Bacterium “ Salinispora pacifica ” by Genome Mining Gives Insight into Pathway Evolution
Author(s) -
Eustáquio Alessandra S.,
Nam SangJip,
Penn Kevin,
Lechner Anna,
Wilson Micheal C.,
Fenical William,
Jensen Paul R.,
Moore Bradley S.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000564
Subject(s) - genome , computational biology , biology , bacteria , gene , genetics
Evolving biosynthesis : Genome mining of the marine bacterium “ Salinispora pacifica ” has led to the discovery of the new proteasome inhibitor, salinosporamide K. Analysis of its biosynthetic gene cluster revealed a loss of gene function in relation to the salinosporamide A biosynthetic locus of Salinispora tropica that accounts for the structural differences in the two natural products.