Premium
Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus
Author(s) -
Kato Naoki,
Suzuki Hirokazu,
Takagi Hiroshi,
Uramoto Masakazu,
Takahashi Shunji,
Osada Hiroyuki
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000562
Subject(s) - aspergillus fumigatus , atp synthase , enzyme , biosynthesis , gene , biochemistry , aspergillus , chemistry , computational biology , stereochemistry , biology , microbiology and biotechnology
Three in one: Verruculogen synthase FtmF is a key enzyme to diversify the fumitremorgin biosynthetic pathway in Aspergillus fumigatus : FtmF catalyzes not only endoperoxide bond formation of verruculogen but also the deprenylation and oxidation of fumitremorgin B to yield 12α,13α‐dihydroxyfumitremorgin C and 13‐oxoverruculogen, respectively.