Gene Disruption and Biochemical Characterization of Verruculogen Synthase of  Aspergillus fumigatus | Zendy

Kato Naoki | Zendy; Suzuki  Hirokazu | Zendy; Takagi Hiroshi | Zendy; Uramoto Masakazu | Zendy; Takahashi Shunji | Zendy; Osada Hiroyuki | Zendy

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Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus

Author(s) -

Kato Naoki,

Suzuki Hirokazu,

Takagi Hiroshi,

Uramoto Masakazu,

Takahashi Shunji,

Osada Hiroyuki

Publication year - 2011

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201000562

Subject(s) - aspergillus fumigatus , atp synthase , enzyme , biosynthesis , gene , biochemistry , aspergillus , chemistry , computational biology , stereochemistry , biology , microbiology and biotechnology

Three in one: Verruculogen synthase FtmF is a key enzyme to diversify the fumitremorgin biosynthetic pathway in Aspergillus fumigatus : FtmF catalyzes not only endoperoxide bond formation of verruculogen but also the deprenylation and oxidation of fumitremorgin B to yield 12α,13α‐dihydroxyfumitremorgin C and 13‐oxoverruculogen, respectively.

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