Genome Mining Reveals  trans ‐AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes | Zendy

Teta  Roberta | Zendy; Gurgui Mihaela | Zendy; Helfrich Eric J. N. | Zendy; Künne Stefan | Zendy; Schneider Andreas | Zendy; Van EchtenDeckert Gerhild | Zendy; Mangoni Alfonso | Zendy; Piel Jörn | Zendy

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Genome Mining Reveals trans ‐AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes

Author(s) -

Teta Roberta,

Gurgui Mihaela,

Helfrich Eric J. N.,

Künne Stefan,

Schneider Andreas,

Van EchtenDeckert Gerhild,

Mangoni Alfonso,

Piel Jörn

Publication year - 2010

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.201000542

Subject(s) - polyketide , phylum , polyketide synthase , bacteroidetes , biology , computational biology , biosynthesis , genome , bacteria , gene , biochemistry , genetics , 16s ribosomal rna

On target: Trans ‐AT polyketide synthases (PKSs) are a recently discovered group of biosynthetic enzymes present in many bacteria. A strategy for the prediction of natural product structures from trans ‐AT PKS sequences was demonstrated to be a useful approach for the targeted isolation of bioactive polyketides from chemically poorly studied prokaryotic phyla, as exemplified by the elansolid‐type antibiotics.

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