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Asymmetric Synthesis and Biological Activity of nor‐α‐Tocopherol, a New Vitamin E Analogue
Author(s) -
Chapelat Julien,
Hengartner Urs,
Chougnet Antoinette,
Liu Kegang,
Huebbe Patricia,
Rimbach Gerald,
Woggon WolfD.
Publication year - 2011
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.201000511
Subject(s) - tocopherol , vitamin e , phytol , chemistry , in vitro , alpha tocopherol , vitamin , biochemistry , stereochemistry , antioxidant
The vitamin E analogues (2 R ,4′ R ,8′ R )‐nor‐α‐tocopherol (94 % de ) and (2 RS ,4′ R ,8′ R )‐nor‐α‐tocopherol have been synthesized from (all R )‐hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor‐α‐tocopherol is an anti‐inflammatory compound more potent than α‐tocopherol.